![]() ![]() ![]() ![]() It can be done either voluntarily or by a tribunal. As it is governed by The Companies Act, there is a standard procedure in place for winding up a company. Similarly, if you are unable to pay your employees or maintain the required health and safety standards, the franchiser reserves the right to end the contract.Īmong the various types of firms, a company's closure is probably the most tedious. However, if you have declared yourself bankrupt, the franchiser himself is likely to terminate your contract. Mutual Funds Spend P2P Data Center Fuel Rates Diesel Rates Petrol Rates Bank Pan Number Bank holidays Penny Stocks MF Ratings & NAV Top Performing Schemes Top Star Rated Schemes Top Tax Saving Schemes Highest Risk Adjusted Return New Fund Offers Forthcoming Dividends NPS Top Performing NPS Scheme Most Consistent NPS schemes ETF Perfomance Latest Prices Listed Bonds Traded in Cash Market ULIPs ULIP Schemes Calculators Recurring Deposit Calculator Fixed Deposit Calculator LTCG Tax Calculator Income Tax Calculator Rent Receipt Generator SIP Calculator IFSC Bank Code NPS Calculator Invoice Generator EPF Calculator House Property Income HRA Calculator Sukanya Samriddhi Calculator Education Loan Calculator Car Loan Calculator Home Loan Calculator Personal Loan Calculator Risk Tolerance Calculator Financial Fitness Calculator Buy Online Health Insurance Car Insurance 2 Wheeler Insurance Interest Rates Recurring Deposit Rates Fixed Deposit Rates Bank Fixed Deposits Rates Post Office Schemes Rates MCLR Loan EMI Participate & Win Stocks & Shares ET Wealth ET Wealth Editions Buy Wealth Magazine ET Wealth NewsletterĪs in any other type of organisation, it is your responsibility to settle the finances. ![]()
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![]() ![]() Once the injured person has established that negligence led to injury, the court calculates the monetary damages that will be paid in compensation. The allegation of medical negligence must be filed in a timely manner this legally prescribed period is called the “statute of limitation” and varies from state to state. To win monetary compensation for injury related to medical negligence, a patient needs to prove that substandard medical care resulted in an injury. In the United States, medical malpractice law has traditionally been under the authority of the individual states and not the federal government, in contrast to many other countries. ![]() Medical Malpractice Law in the United States The goal of this article is to provide orthopaedic surgeons an introduction to the basic concepts of medical malpractice law, including the language, court structure, and tribunals that govern medical malpractice litigation in the United States. Once a lawsuit is filed, the defendant physician must deal with unfamiliar legal territory, where the goals, professional conduct, and procedures followed by the parties to the litigation are different from the practice of medicine. Since medical malpractice litigation is a pervasive phenomenon, it is likely surgeons will encounter it at some point in their career. One survey of specialty arthroplasty surgeons reported that more than 70% of respondents had been sued at least once for medical malpractice during their career. Since the 1960s the frequency of medical malpractice claims has increased and today, lawsuits filed by aggrieved patients alleging malpractice by a physician are relatively common in the United States. However, before the 1960s, legal claims for medical malpractice were rare, and had little impact on the practice of medicine. In the United States, medical malpractice suits first appeared with regularity beginning in the 1800s. ” In 1532, during the reign of Charles V, a law was passed that required the opinion of medical men to be taken formally in every case of violent death this was the precursor to requiring expert testimony from a member of the profession in medical negligence claims, to establish the standard of care. One early medical malpractice case from England, for example, held that both a servant and his master could sue for damages against a doctor who had treated the servant and made him more ill by employing “unwholesome medicine. These records provide an unbroken line of medical malpractice decisions, all the way to modern times. After the Norman conquest of 1066, English common law was developed, and during the reign of Richard Coeur de Lion at the close of the 12th century, records were kept in the Court of Common Law and the Plea Rolls. Around 1200 AD, Roman law was expanded and introduced to continental Europe. Under Roman law, medical malpractice was a recognized wrong. Writings on medical responsibility can be traced back to 2030 BC when the Code of Hammurabi provided that “If the doctor has treated a gentlemen with a lancet of bronze and has caused the gentleman to die, or has opened an abscess of the eye for a gentleman with a bronze lancet, and has caused the loss of the gentleman’s eye, one shall cut off his hands. The concept that every person who enters into a learned profession undertakes to bring to the exercise of a reasonable degree of care and skill dates back to the laws of ancient Rome and England. ![]() ![]() ![]() ![]() Smokers are warned this is a strong smoke and, as the name suggests, users can often turn their brains off completely after a session. The flavour is fresh and fruity like you expect from a haze which only makes the smoke so much more enjoyable. Royal Queen Seeds' Amnesia Haze really is one of the best cannabis strains in our entire stock.Įvery hit comes with a truly psychedelic head high, likely to send any user straight into the astrosphere. After your 1st joint or bong we are certain you will be more than satisfied with the smoke after waiting such a long time. So after 4 months of growing, 2 weeks of drying and curing and your finally ready to smoke the Amnesia haze that has taken you so long to grow. Amnesia haze is suitable for both hydro and soil grows, sea/screen of green too. Although this is high enough to make most commercial growers run for the hills, true cannabis connoisseurs will find the wait more than worth it. It’s not to be confused with Amnesia - a cross of Bubble Gum and Super Silver Haze - that was grown in Amsterdam and bred in California by David Paul Watson (aka Sam the Skunkman. As the clocks hands start to move, the Amnesia Lemon strain slows down your mind’s thoughts while you swim away from your daily issues into Morpheus’s arms. The only down side with Amnesia haze is the long flower time required of 12 weeks. Description Bred by Amsterdam’s Soma Seeds, Amnesia Haze is a complex cross of Haze with Southeast Asian, Afgani and Hawaiian landrace strains. However extra care should be taken outdoors as this is a sensitive plant, so problems with weather, bugs or irrigation will harm your final harvest. She can produce big outside, with full sun, reaching as much as 700g per plant. Offers the best deal on all weed and products. The Amnesia gives a strong psychedelic high that is accompanied by euphoric and energetic feelings. Add to cart 139. Up to 18oz of weed from a large, dense plant. Earthy citrus paves the way for tropical flavors. She can be grown outdoors but will require hot weather like Australia, North Africa and California, however may need to be grown in a greenhouse due to her long flower period.Īmnesia haze is one of Royal Queen Seeds' best yielding cannabis strains, producing 70-80 g per plant with up to 600g per metre squared under a 600w light. Amnesia Chiangrai is a cannabis dispensary located in downtown Chiangrai. Amnesia Purple Feminized Cannabis Seeds Lavender-painted, stress-busting goodness. Royal Queen Seeds' Amnesia haze is a well maintained plant growing just over a metre tall, to about 1.2m. Royal Queen Seeds felt their collection of marijuana seeds would not be complete without one of the best hazes to ever be smoked, so Royal Queen Seeds got a hold of some Amnesia and made feminised seeds. After the haze genetics came to Holland and several hybrids were made, an American expat would later combine one of these hybrids with a male derived from old school haze seeds creating the Amnesia Haze. ![]() ![]() ![]() So what's WhatsApp? Let's find out the features and outstanding features of the WhatsApp application! 1.What’s WhatsApp? What’s Whatsapp Web? WhatsApp is one of the free messaging and calling applications on phones and computers used by many people. When end-to-end encrypted, your messages and calls are secured so only you and the person you're communicating with can read or listen to them, and nobody in between, not even WhatsApp.īecoming the world's most popular messaging application, despite strong competition from Messenger, Viber or Wechat, WhatsApp is clearly proving its huge appeal. Some of your most personal moments are shared on WhatsApp, which is why we built end-to-end encryption into the latest versions of our app. You can also name your group, mute or customize notifications, and more. With group chats, you can share messages, photos, and videos with up to 256 people at once. Keep in touch with the groups of people that matter the most, like your family or coworkers. WhatsApp Message uses your phone's Internet connection to send messages so you can avoid SMS fees. Message your friends and family for free*. The letter cases would depend on the caps lock on your system, if you want to type a text with first letter in caps then you would have to use Shift/Cmd key.If your phone isn’t nearby, doesn't have active internet connection or is switched off then in these cases you can’t use the same on your laptop. ![]() If your phone is on charging then you can use it on your system.Share files, copy and paste is so quick.Can revert while attending a call on phone/laptop.You don’t skip your messages while being away from your smartphone.Scan the code and you’re ready to use your WhatsApp on your laptop.Go to Settings > Linked Devices > Click on “Link a Device” for iOS users or Click on three dots at right top bar > Click on Scan Code icon on right top bar for Android usrers.Type WhatsApp Web on Google/Bing/Yahoo or any surfing platform you have the access to.One can access the WhatsApp Web by following these steps: In this case you don’t hamper your productivity neither skip any important message. WhatsApp Web is website about online version of WhatsApp Business or WhatsApp, so that you don’t have to rely on your phone only while you’re working on your system. Watch for them and have your QR Code reader handy! Once you get the hang of it, QR Codes will save you a lot of time and effort. ![]() They are used to educate, inform, explain, and for many other reasons. You will begin to see QR codes all over the place. It may take a few seconds on most devices. Presto! Your smartphone reads the code and navigates to the intended destination, which doesn’t happen instantly. On some readers, you have to press a button to snap a picture, not unlike the button on your smartphone camera. Two things can happen when you correctly hold your smartphone over a QR Code. Hold your device over a QR Code so that it’s clearly visible within your smartphone’s screen. ![]() ![]() ![]() You can check that you miss no other fonts. This time WPS Office should open it very rapidly. Copy the missing fonts in a directory in fontconfig search path (for instance, /usr/share/fonts/) Go on the web and download the fonts that you miss. In the following example, we miss only one font, "Tahoma"Ĭlose WPS. On the left you find the missing fonts, on the right the fonts that have been used as a substitute. There was also another spreadsheet file format. ![]() The "Font Substitution" window should appear. WPS is the Works Word Processor file format that was part of the Works suite along with.This format very similar to Microsoft Word Documents (DOC) and it was replaced by. Once the document is loaded, go to Menu -> Options WPS Office is an office suite for PDF, Word, Excel, and PPT files. WPS files are documents, used by Microsoft Works Word Processor Document.Wait patiently until your document is loaded.If the document is written with fonts that are missing on the system, WPS Office engage in lengthy process of font substitution, and apparently that process is much more lengthy in ver. Download WPS Registration form, fill in the company details, sign it and submit it to your QNB Corporate Branch. The snap version blocks internet access by default, the. Forbidding WPS from accessing the internet makes opening a document significantly faster. NEW ANSWER: It may be due to accessing the internet. Graphics Processor: GeForce GTX 1060/PCIe/SSE2 Processors: 12 × Intel® Core™ i7-8750H CPU 2.20GHz My system is: Operating System: Kubuntu 20.10 ![]() This does not answer my question as it redirects in installing WPS from snap. I don't even think that the command is correct: if I run WPS Office with et -style=XXX, I can put whatever I want in XXX and it never throws any error, and I notice no difference whatsoever, nor in terms of UI nor in terms of file opening times (not even with the proposed -style=motif). The solution here, which implies changing the theme on which WPS Office runs, unfortunately does not work for me. Windows will automatically open the file using Microsoft Word or a compatible viewer program on your computer. docx file that WPS Office takes 15 seconds to open, while LibreOffice Writer opens it in 1/2 seconds. 1.Double-click on the WPS file you want opened. This version of WPS Office is very slow in opening some files.įor example, I have this. ![]() ![]() ![]() Storyboard Pro contains all the tools required to create storyboards and animatics. This software is used in pre-production to create storyboards for a wide variety of project types including 2D and 3D animation, stop motion, and live action productions. Harmony Server is available as an add-on for users of Harmony Advanced and Harmony Premium. It also includes production controls for managing rendering jobs and coordinating batch scanning of paper drawings. Its centralized database system allows the sharing of assets between scenes and enables the workload to be shared across a studio or between studios. This software provides additional capabilities for teams of animators using Harmony who want to share files and manage assets from a central database that is located on a server. Harmony has also been used by content creators on YouTube. Harmony has been in continuous development since 2005 and has been used on productions like Curious George, The Simpsons Movie, Disney's The Princess and the Frog and Winnie the Pooh, The SpongeBob Movie: Sponge Out of Water, My Little Pony: The Movie, Space Jam: A New Legacy, and The Bob's Burgers Movie among others. Users can also draw animation directly into the software, using a graphics tablet. Its toolset includes pencil lines with textures, deformation tools, morphing, inverse kinematics, particles, built-in compositor, 3D camera and 2D-3D integration. Harmony contains the tools required to handle cutout (puppet), paperless frame-by-frame and traditional animation workflows from scanning to compositing and 2D/3D integration. The application included built-in video tutorials by the cartoonist.Įnglish, Spanish, Japanese, and Chinese
![]() ![]() If you have played games like Devil May Cry, Ninja Gaiden or indeed previous Platinum Games hit, Bayonetta, you will know what to expect from Revengeance. It’s not the deepest or most engaging story I’ve seen in a game, but it does provide ample of excuses for running around and cutting enemies into bacon thin strips. In typical Metal Gear tradition the plot involves lots of talk about war economy and politics, but Raiden’s main concern is saving some orphans from a very tragic fate. Raiden is now working for a private military company called Maveric Securities and comes to blows with Desperado Enterprises who seem to have their own agenda. Storywise the game is set four years after the events of Metal Gear Solid 4. ![]() Just give one of Raidens’ comrades a call while inside a cardboard box to hear their opinion on a highly advanced cyborg ninja hiding from enemies in a box. Raiden can sneak up on enemies for a ninja kill and skulk about in a cardboard box if you wish, but this is not what the game is about and attempting to play it like Raiden is Snake will just end in tears. ![]() The first thing to realize about Revengeance is that if you are expecting stealth based gameplay like you are used to in the Metal Gear Solid games then you are in the wrong place. This would have been the end of the story if it wasn’t for Platinum games, developers of Vanquish and Bayonetta stepping in and offering their services. Unfortunately the game was cancelled due to the inexperienced team struggling to fully capitalize on the sword based gameplay. His return as a cyborg ninja in Metal Gear Solid 4 did a lot to raise coolness quota and actually earned him a shot at his own game. Raiden’s first appearance in Metal Gear Solid 2 didn’t exactly win the character many fans. ![]() ![]() ![]() Both of these are additional purchases, but are excellent additions. If one is making a long recording such as a book, TwistedWave will recognize the words of the audio and synchronize it with the text. New to TwistedWave is speech recognition. ![]() I can also batch process files with changes such as fade in/out, etc. The application can convert audio files to different formats. I can equalize, compress, or use hundreds of audio plugins. If you have two red marks the cursor can easily select between them snapping to your lines so you can correct exactly the area you marked. Often when listening back, if there is a mistake, I just click “m” and immediately the file is marked with a red line so I can easily find it later. ![]() It’s easy to zoom into a certain time in your recording or see the entire audio file. The sound bars on the side that rise and fall with my audio levels help keep the audio consistent.= I really like how I can see the waveform as I record and then can go back and easily select areas with mistakes, simply delete them, and re-record. After using it for only a short time, TwistedWave has become the application I use for all my audio recordings and editing. I then reached out to the developer to see if I could get a full copy to try all the features and to write a review, to which he agreed. I tried the trial version and really liked the application. I was very wrong and glad I gave it a chance. I thought that software developed by one person would be lacking in appearance and performance. I must admit, I was hesitant to use TwistedWave because it is written by one person. TwistedWave does all I need and so much more. I want a clean, professional app, and I found exactly that in TwistedWave. There are even some purchased apps that have embedded ads encouraging me to buy their other products. There are some free and “shareware” apps, but those just do not seem very professional with the look and performance on the Mac. I need to simply record, edit the waveform, and then save. GarageBand and Logic Pro from Apple are overly complex for what I need. You should enable JavaScript in order to use TwistedWave Online. TwistedWave Online Audio Editor JavaScript is required. There are many on the market, but none seemed to be what I was looking for. You only need a web browser to access it, and you can use it to record or edit any audio file. Now your audio should be available on your Google Drive, and it is time to insert it into your Google Slides.I’ve been using a Mac for many years and prefer it for many reasons, but I’ve struggled to find a good audio editor. Another way to upload your audio clip is to click New > File upload > Browser to your file, select it and then click Open. Sie können das Abschneiden von TwistedWave Recorder tages- und stundengenau für verschiedene Länder, Kategorien und Geräte nachverfolgen. App Store ist und wie sich dieser Wert im Lauf der Zeit entwickelt hat. Chrome OS 69 or later support running containerized Linux.ĭrag and drop the audio file into your drive. Der Ranking-Verlauf zeigt an, wie beliebt TwistedWave Recorder im Deutschland. You cannot run Audacity on a Chromebook because Audacity does not support Chrome OS. We cover preferences, setting levels, and basic. Vocaroo is an essential however helpful audio recording software for Chromebooks.Ĭorrespondingly, can I use Audacity on a Chromebook? 1.02K subscribers Subscribe 5.9K views 2 years ago CHICAGO This is a short tutorial on setting up Twisted Wave for home use as a voice over. Subsequently, question is, what is the best audio recorder for Chromebook? Best Audio Recorders for Chromebook It contains numerous features to import, export, duplicate, split, trim, modify the speed, increase the volume, merge, etc, audio files. AudioStudio is an audio editor to create or modify any music or audio file. TwistedWave is an amazingly full-featured audio editor that allows the users to edit audio files and recording from one’s computer or google drive, apply effects on it, and save in so many supported file formats which can also be export back to one’s disk, Soundcloud or even Google Drive.Īlso to know is, does Google have an audio editor?ĪudioStudio – Google Workspace Marketplace. ![]() ![]() Uh I have’t seen that many of her tbh but i like the aus that have her as this cooky vodka aunt type. I think if it wasn’t cut in layers i’d like it better. I’m….not the biggest fan of her hair in mkx. She’s isn’t someone I’d like to see necessarily redeemed perse, but having her and Mileena forced to unite w Jade and Kitana to fight a common enemy and leaving that journey with a mutual feeling of respect for each other seems nice. Hearing Mileena say “Dearest Tanya” makes my gay little heart flutter tbh Nothing in particular but I love seeing how soft she and Mileena are to each other in their interactions. It also makes seeing Tanya actually loyal to someone have some weight to it. In Mortal Kombat: Armageddon Sareena follows Sub-Zero into the Netherrealm, saving him from being killed by Noob Saibot and Smoke. Like she has a personality outside of “backstabber in it for her own survival” which is already more than what u can say about D’vorah. Like she is absolutely that bitch but also imo more likable and less needlessly traitorous. There are, however, some that deserve to be featured in the next game for certain.- I like her, and I feel like she’s D’vorah done right. Sareena is a demon who made her first appearance in Mortal Kombat Mythologies: Sub-Zero as a non-playable boss character. Mortal Kombat, over its decades of existence, has garnered an impressive collection of unique characters. As is the norm for fighting games, fans are already theorycrafting and making lists of their perfect roster. I used a picture of Gong Li as a reference for her facial features. Hopefully I'll be able to finish it in the future. She went through the portal and is transported to Outworld where she later discovered a way to restore her human form without Quan Chi's magic by absorbing the energy of the realm. Ashrah MK1 - WIP - I really wanted to fully redesign her but I don't have time cause of my final exams. What fans do have is relentless trolling from Ed Boon on Twitter, and rumors and leaks, which have revealed that Mortal Kombat 12 is set to release in 2023. After years of being trapped, Sareena discovered the portal Quan Chi and Scorpion used to escape the Netherealm shortly before Mortal Kombat: Deadly Alliance. There hasn't been a new game from Netherrealms in a while and there hasn't been much in the way of news or updates to keep fans excited either. Discover the growing collection of high quality Most Relevant XXX movies and clips. Discovery made the announcement during its earnings call today. Watch Mortal Kombat Sareena porn videos for free, here on. RELATED: Best Fighters In Mortal Kombat 11, Ranked Mortal Kombat 12 is set to release this year, making 2023 an absolute juggernaut of a year for fighting games. The characters, the situations, the plots, the -everything- is strictly there in service of creating absurd conflicts to have fight scenes, or absurd and silly cinematics. She lay unconscious atop the pyramid until Sub-Zero revived her. Dont engage with these people that are looking for a narrative that simply is never going to exist. ![]() ![]() Mortal Kombat 11 had incredible graphics, some of the best animations in any fighting game out there, and a jaw-dropping roster, featuring the likes of Rambo and Spawn. Blaze had dissipated, but the power he had released flowed into Sareena. Past versions of all the characters have disappeared. way possible Mortal Kombat 12 is an upcoming fighting game in the Mortal Kombat series. Fire God Liu Kang has summoned Nightwolf and Fujin, who were released during the dead of Shang Tsung, human Raiden, Sub-Zero, Jax, Jacqui. The final piece of DLC for Mortal Kombats Aftermath expansion. As repayment for helping him, Sub-Zero invited her into. ![]() She eventually betrayed him to help Sub-Zero, which led to her being tortured. ago Bruh, Kuai Liang saved Hanzo Hasashi many times, are they on an gay relationship no, also Mortal Kombat Mythologies passes on maximum two years before the tenth Mortal Kombat happens and Sareena wasnt actually freed from Netherworld or whatever at that time. It featured a high-budget, blockbuster-style story mode with an incredible DLC expansion pack as well. 01:59 PM EST The story begins directly after Aftermath’s events. Sareena was a demon under the service of Quan'Chi. Mortal Kombat 11 has continued the trend of new Mortal Kombat games being absolutely amazing. TheLolHounds 2.0 374K subscribers Subscribe Share 51K views 2 months ago Mortal Kombat 12 Character Concept Art for a full roster created by AI. ![]() ![]() A novel member of vertebrate eIF2α kinase, named PKZ (protein kinase containing Zα binding domains), has been identified exclusively in fish ( 28– 30). While the findings on RNA-recognizing PRRs in fish are quite clear, those on DNA-recognizing PRRs are ambiguous. Along with the discovery of RNA sensors in mammals, RLRs (RIG-I, MDA5, and LGP2) and TLRs, which are involved in dsRNA recognition, were also identified in teleost fish ( 22– 27). In recent years, much progress has been made in the study of fish PRRs. Recognition of viral DNA by cGAS induces the synthesis first of the second message cGAMP from ATP and GTP, and then of cGAMP which binds to STING and STING enhances IRF3 phosphorylation by TBK1, thus activating downstream genes ( 17– 21). Cyclic GMP-AMP synthase (cGAS) is known to detect cytosolic DNA in various cell types ( 16). For example, IFI16 is a sensor for HIV DNA through interaction with stimulator of IFN gene (STING), and is also important in inducing IFN-β reactions in human macrophages ( 13). These proteins are important in responding to various DNA infections. In addition to the RNA sensors described above, a number of intracellular DNA sensors have been confirmed in recent times, such as absent in melanoma 2 (AIM2) ( 11), DNA-dependent activator of IFN-regulatory factors (DAI) ( 12), IFN-inducible protein 16 (IFI16) ( 13), DEAD (Asp-Glu-Ala-Asp) box polypeptide 41 (DDX41) ( 14), RNA polymerase III ( 15), and Cyclic GMP-AMP synthase (cGAS) ( 16). RLRs (RIG-I and MDA5) detect cytosolic RNA via the adaptor protein IPS-1 and activate IFN-β signaling pathways ( 10). TLR3 recognizes double-stranded RNA (dsRNA), and then triggers IFN-β expression by activating interferon transcription factor 3 (IRF3) and nuclear factor κB (NF-κB) ( 8, 9). A few toll-like-receptors (TLR) and RIG-I-like receptors (RLR) are known to detect bacterial and viral RNAs ( 6, 7). In recent years, many complicated and effective PRRs have been identified in mammals. Pattern-recognition receptors (PRRs) that recognize pathogen-associated molecular patterns (PAMPs) play vital roles in initiating IFN signaling pathways ( 3– 5). Innate immunity is the first defense line for vertebrates, especially lower vertebrates, to fight off invading pathogens ( 1, 2). PKZ activates IFN expression through IRF3- or ISGF3-like-dependent pathway. In vitro, PKZ can be activated by poly (dA:dT)- or poly (dG:dC)-PKZ interaction, but PKZ cannot interact with RNA. The expression pattern of PKZ is similar to those of IRF3-dependent and ISGF3-like-dependent mediators. These results demonstrate that PKZ acts as a special DNA pattern-recognition receptor, and that PKZ can trigger immune responses through IRF3-mediated or ISGF3-like mediated pathways in fish. Further investigations have revealed that PKZ can activate IRF3 and STAT2 and that IRF3-dependent and ISGF3-like dependent mediators are critical for PKZ-induced IFN expression. Meanwhile, co-IP assays have shown that PKZ can separately interact with IRF3, STING, ZDHHC1, eIF2α, IRF9, and STAT2. Subcellular localization assays have also shown that PKZ is located in the cytoplasm, which suggests that PKZ acts as a cytoplasmic PRR. These findings indicate that PKZ participates in cytoplasmic DNA-mediated signaling. DNA-PKZ interaction can enhance PKZ phosphorylation and dimerization in vitro. The expression pattern of PKZ is similar to those of innate immunity mediators stimulated by poly (dA:dT) and poly (dG:dC). Herein, we have found that PKZ acts as a fish-specific DNA sensor by initiating IFN expression through IRF3- or ISGF3-like mediated pathways. PKZ is known to induce apoptosis through phosphorylating eukaryotic initiation factor 2α kinase (eIF2α) in the same way as double-stranded RNA-dependent protein kinase (PKR), but its exact role in detecting pathogens remains to be fully elucidated. PKZ is a fish-specific protein kinase containing Zα domains. 2Fuzhou Medical College, Nanchang University, Fuzhou, China.1College of Life Science, Nanchang University, Nanchang, China.Xiaowen Xu 1, Meifeng Li 1, Chuxin Wu 1, Dongming Li 2, Zeyin Jiang 1, Changxin Liu 1, Bo Cheng 1, Huiling Mao 1 and Chengyu Hu 1 * ![]() |
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